Introduction: Supervised machine learning classifiers sometimes face challenges related to the performance, accuracy, or overfitting. Methods: This paper introduces the Artificial Liver Classifier (ALC), a novel supervised learning model inspired by the human liver's detoxification function. The ALC is characterized by its simplicity, speed, capability to reduce overfitting, and effectiveness in addressing multi-class classification problems through straightforward mathematical operations. To optimize the ALC's parameters, an improved FOX optimization algorithm (IFOX) is employed during training. Results: We evaluate the proposed ALC on five benchmark datasets: Iris Flower, Breast Cancer Wisconsin, Wine, Voice Gender, and MNIST. The results demonstrate competitive performance, with ALC achieving up to 100% accuracy on the Iris dataset-surpassing logistic regression, multilayer perceptron, and support vector machine-and 99.12% accuracy on the Breast Cancer dataset, outperforming XGBoost and logistic regression. Across all datasets, ALC consistently shows smaller generalization gaps and lower loss values compared to conventional classifiers. Discussion: These findings highlight the potential of biologically inspired models to develop efficient machine learning classifiers and open new avenues for innovation in the field.